Back to Search Start Over

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa

Authors :
Zoltán Béni
Miklós Dékány
Bernadett Kovács
Boglárka Csupor-Löffler
Zoltán Péter Zomborszki
Erika Kerekes
András Szekeres
Edit Urbán
Judit Hohmann
Attila Ványolós
Source :
Molecules, Vol 23, Iss 5, p 1082 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.

Details

Language :
English
ISSN :
14203049
Volume :
23
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.6c849d83f1bd4b97831c501f847635f7
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules23051082