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Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- Otosclerosis is a common form of hearing loss, with an unclear genetic etiology. Here, the authors perform a genome-wide association study meta-analysis of otosclerosis identifying 27 genetic loci, pointing to genes involved in bone remodeling, skeletal disorders and transforming growth factor β signaling.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6c545f6161e84ab58fce429684406cdc
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-32936-3