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Identification of atrial fibrillation associated genes and functional non-coding variants

Authors :
Antoinette F. van Ouwerkerk
Fernanda M. Bosada
Karel van Duijvenboden
Matthew C. Hill
Lindsey E. Montefiori
Koen T. Scholman
Jia Liu
Antoine A. F. de Vries
Bastiaan J. Boukens
Patrick T. Ellinor
Marie José T. H. Goumans
Igor R. Efimov
Marcelo A. Nobrega
Phil Barnett
James F. Martin
Vincent M. Christoffels
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and functional non-coding variants.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6c47420fc1c646169658c86522780b7c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12721-5