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Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19

Authors :
Graham J. Britton
Alice Chen-Liaw
Francesca Cossarini
Alexandra E. Livanos
Matthew P. Spindler
Tamar Plitt
Joseph Eggers
Ilaria Mogno
Ana S. Gonzalez-Reiche
Sophia Siu
Michael Tankelevich
Lauren Tal Grinspan
Rebekah E. Dixon
Divya Jha
Adriana van de Guchte
Zenab Khan
Gustavo Martinez-Delgado
Fatima Amanat
Daisy A. Hoagland
Benjamin R. tenOever
Marla C. Dubinsky
Miriam Merad
Harm van Bakel
Florian Krammer
Gerold Bongers
Saurabh Mehandru
Jeremiah J. Faith
Source :
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Abstract Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.6c31edc6052419cbb41e75506d8cb06
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-021-92740-9