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H/D Exchange Using Hot Heavy Water
- Source :
- CHIMIA, Vol 72, Iss 12 (2018)
- Publication Year :
- 2018
- Publisher :
- Swiss Chemical Society, 2018.
-
Abstract
- Metal-catalyzed H/D exchange in hydrothermal deuterium oxide, performed in an autoclave using external heating or in a sealed glass tube under microwave irradiation, was shown to be an efficient method for preparing various deuterium-labeled compounds. Phosphonium salts for the Wittig reaction were deuterated at the ?-position in the presence of MS 4A under microwave irradiation; primary alcohols and primary/secondary amines were deuterated at the ?-position in the presence of ruthenium catalyst under microwave irradiation; metal-catalyzed direct C–H functionalizations on sp3 and sp2 carbon gave the corresponding fully deuterated products under hydrothermal conditions. These methods gave various deuterium-labelled compounds efficiently using D2O as a D-atom source.
- Subjects :
- H/d exchange
Hydrothermal
Microwaves
Palladium
Platinum
Ruthenium
Chemistry
QD1-999
Subjects
Details
- Language :
- German, English, French
- ISSN :
- 00094293 and 26732424
- Volume :
- 72
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- CHIMIA
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6bd86279a0be4ec8a8ac45de23eaf7fe
- Document Type :
- article
- Full Text :
- https://doi.org/10.2533/chimia.2018.853