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Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling
- Source :
- Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Rap1 deficiency in T cells impairs development or maintenance of RorĪ³t+ Tregs in the colonic lamina propria, leading to an increase in pathogenic Th17 cells and development of spontaneous colitis.
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 5
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Communications Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6bca71fa12fc48b480cc2623bf13312a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s42003-022-03129-x