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Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6bac542d07b431a964d07a618a8a4d6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10622