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New options in the management of intractable ALK(+) metastatic non-small-cell lung cancer
- Source :
- Lung Cancer: Targets and Therapy, Vol 2014, Iss default, Pp 35-42 (2014)
- Publication Year :
- 2014
- Publisher :
- Dove Medical Press, 2014.
-
Abstract
- Amy M Weise, Shirish Gadgeel Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA Abstract: Non-small-cell lung cancer (NSCLC) is a heterogeneous disease and a challenging malignancy to treat, as many patients have advanced disease at the time of diagnosis. Recent advances have led to the identification of molecularly defined subtypes of NSCLC, namely for patients with adenocarcinoma histology. The most recently identified molecular target is the anaplastic lymphoma kinase (ALK) gene rearrangement, and patient responses to the ALK inhibitor crizotinib have led to its approval in this selected patient population. Like other tyrosine kinase inhibitors, resistance to crizotinib ultimately develops by various mechanisms requiring alternative therapeutic options. This review article discusses the management of patients with the ALK gene rearrangement, mechanisms of crizotinib resistance, and future potential therapeutic options. Keywords: non-small-cell lung cancer, disease management, cancer therapy
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 11792728
- Volume :
- 2014
- Issue :
- default
- Database :
- Directory of Open Access Journals
- Journal :
- Lung Cancer: Targets and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6b5e8573f5a4b288ba89c3869688421
- Document Type :
- article