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Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers

Authors :
James J. Harding
Sarina A. Piha-Paul
Ronak H. Shah
Jessica J. Murphy
James M. Cleary
Geoffrey I. Shapiro
David I. Quinn
Irene Braña
Victor Moreno
Mitesh Borad
Sherene Loi
Iben Spanggaard
Haeseong Park
James M. Ford
Mónica Arnedos
Salomon M. Stemmer
Christelle de la Fouchardiere
Christos Fountzilas
Jie Zhang
Daniel DiPrimeo
Casey Savin
S. Duygu Selcuklu
Michael F. Berger
Lisa D. Eli
Funda Meric-Bernstam
Komal Jhaveri
David B. Solit
Ghassan K. Abou-Alfa
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

In biliary tract cancer HER2 alterations correlate with poor prognosis. Here, the authors present the results of a phase II clinical trial reporting the efficacy and safety of the tyrosine kinase inhibitor neratinib in patients with HER2-mutation positive advanced biliary tract cancers.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6b0c6dc798b14d37bd9664bd41aec7e1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36399-y