Effect of Bifendate Derivatives on Diabetic Nephropathy and Renal Function

Objective To explore the mechanism of bifendate derivatives in improving diabetic nephropathy and renal function. Methods Fifty SPF grade 6-8 week old C57BL/6J mice, of which, 15 were in the control group and 35 in the diabetic nephropathy model group. The mice in the control group were divided into a normal control group (n=7) and a control administration group (n=8), and the mice in the diabetic nephropathy model group were divided into model group, low-dose administration group, medium-dose administration group, high-dose administration group, and resveratrol-positive drug group (each had 7 mice). Samples were taken after 8 weeks of drug administration. The basic parameters and renal function related indexes of mice were detected, glycogen staining experiments detected the accumulation of glycogen in renal tissues, Sirius red staining detected the fibrosis of renal tissues, and proteomic analysis was performed by Q-Exactive mass spectrometer. The differences of the indexes between the comparison groups were analyzed. Results Different doses of bifendate derivatives significantly reduced fasting blood glucose in mice (P