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Active glucose transport varies by small intestinal region and oestrous cycle stage in mice
- Source :
- Experimental Physiology, Vol 108, Iss 6, Pp 865-873 (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract Food intake changes across the ovarian cycle in rodents and humans, with a nadir during the pre‐ovulatory phase and a peak during the luteal phase. However, it is unknown whether the rate of intestinal glucose absorption also changes. We therefore mounted small intestinal sections from C57BL/6 female mice (8–9 weeks old) in Ussing chambers and measured active ex vivo glucose transport via the change in short‐circuit current (∆Isc) induced by glucose. Tissue viability was confirmed by a positive ∆Isc response to 100 µM carbachol following each experiment. Active glucose transport, assessed after addition of 5, 10, 25 or 45 mM d‐glucose to the mucosal chamber, was highest at 45 mM glucose in the distal jejunum compared to duodenum and ileum (P
- Subjects :
- oestrous cycle
glucose
mouse
SGLT1
small intestine
Physiology
QP1-981
Subjects
Details
- Language :
- English
- ISSN :
- 1469445X and 09580670
- Volume :
- 108
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Experimental Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6b078852cf6c4c2290d0dd9fcadd9f1e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1113/EP091040