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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Authors :
Jayaram Vijayakrishnan
James Studd
Peter Broderick
Ben Kinnersley
Amy Holroyd
Philip J. Law
Rajiv Kumar
James M. Allan
Christine J. Harrison
Anthony V. Moorman
Ajay Vora
Eve Roman
Sivaramakrishna Rachakonda
Sally E. Kinsey
Eamonn Sheridan
Pamela D. Thompson
Julie A. Irving
Rolf Koehler
Per Hoffmann
Markus M. Nöthen
Stefanie Heilmann-Heimbach
Karl-Heinz Jöckel
Douglas F. Easton
Paul D. P. Pharaoh
Alison M. Dunning
Julian Peto
Frederico Canzian
Anthony Swerdlow
Rosalind A. Eeles
ZSofia Kote-Jarai
Kenneth Muir
Nora Pashayan
The PRACTICAL Consortium
Mel Greaves
Martin Zimmerman
Claus R. Bartram
Martin Schrappe
Martin Stanulla
Kari Hemminki
Richard S. Houlston
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6a850276ab0d4ba1a6215db9280b774f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-03178-z