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The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.

Authors :
Francesca Rossi
Maria Ester Bernardo
Giulia Bellini
Livio Luongo
Antonella Conforti
Iolanda Manzo
Francesca Guida
Luigia Cristino
Roberta Imperatore
Stefania Petrosino
Bruno Nobili
Vincenzo Di Marzo
Franco Locatelli
Sabatino Maione
Source :
PLoS ONE, Vol 8, Iss 11, p e80022 (2013)
Publication Year :
2013
Publisher :
Public Library of Science (PLoS), 2013.

Abstract

Mesenchymal stromal cells are non-hematopoietic, multipotent progenitor cells producing cytokines, chemokines, and extracellular matrix proteins that support hematopoietic stem cell survival and engraftment, influence immune effector cell development, maturation, and function, and inhibit alloreactive T-cell responses. The immunosuppressive properties of human mesenchymal stromal cells have attracted much attention from immunologists, stem cell biologists and clinicians. Recently, the presence of the endocannabinoid system in hematopoietic and neural stem cells has been demonstrated. Endocannabinoids, mainly acting through the cannabinoid receptor subtype 2, are able to modulate cytokine release and to act as immunosuppressant when added to activated T lymphocytes. In the present study, we have investigated, through a multidisciplinary approach, the involvement of the endocannabinoids in migration, viability and cytokine release of human mesenchymal stromal cells. We show, for the first time, that cultures of human mesenchymal stromal cells express all of the components of the endocannabinoid system, suggesting a potential role for the cannabinoid CB2 receptor as a mediator of anti-inflammatory properties of human mesenchymal stromal cells, as well as of their survival pathways and their capability to home and migrate towards endocannabinoid sources.

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
11
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.6a34c07ff6d54117a5ef39e4162983be
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0080022