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GPi/GPe borderland– a potential sweet spot for deep brain stimulation for chorea in Huntington’s disease?

Authors :
Julia Steinhardt
Simone Zittel
Vera Tadic
Volker Tronnier
Christian Moll
Tobias Bäumer
Alexander Münchau
Dirk Rasche
Norbert Brüggemann
Source :
Neurological Research and Practice, Vol 6, Iss 1, Pp 1-3 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background Pallidal deep brain stimulation (GPi-DBS) has been considered as an effective treatment option for medication-refractory Huntington’s disease (HD). Objectives To identify stimulation-dependent effects on motor symptoms and to determine if these alterations are associated with the local impact of DBS on different pallidal parcellations. Methods We prospectively evaluated the effects of bilateral GPi-DBS within one year in 5 HD patients. We evaluated the effects of GPi-DBS on choreatic symptoms and UHDRS. Electrode placement in the pallidum was localized, and the local impact of DBS was estimated. Results The chorea subscore (p

Details

Language :
English
ISSN :
25243489
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Neurological Research and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.699c4155182a4c4cbe0fcf5882e3d416
Document Type :
article
Full Text :
https://doi.org/10.1186/s42466-024-00316-5