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Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

Authors :
Shun Li
Florian olde Heuvel
Rida Rehman
Oumayma Aousji
Albrecht Froehlich
Zhenghui Li
Rebecca Jark
Wanhong Zhang
Alison Conquest
Sarah Woelfle
Michael Schoen
Caitlin C. O´Meara
Richard Lee Reinhardt
David Voehringer
Jan Kassubek
Albert Ludolph
Markus Huber-Lang
Bernd Knöll
Maria Cristina Morganti-Kossmann
Marisa M. Brockmann
Tobias Boeckers
Francesco Roselli
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Il-13 is expressed in neurons and IL-13 ko causes memory impairment. Here, authors show that IL-13 and its receptor IL-13Ra1 are pre- and post-synaptic proteins, respectively, involved in synaptic signaling, plasticity and neuroprotection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6966d3478aa47859f429edf593265f2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-35806-8