Back to Search Start Over

sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy

Authors :
Szymon Kozłowski
Anna Stelmaszczyk-Emmel
Iwona Szymusik
Aleksandra Saletra-Bielińska
Robert Brawura-Biskupski-Samaha
Paweł Pietruski
Agnieszka Osińska
Katarzyna Kosińska-Kaczyńska
Source :
Diagnostics, Vol 11, Iss 7, p 1181 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation.

Details

Language :
English
ISSN :
20754418
Volume :
11
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.695a289e84774d0da64f3d5e81e527cf
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics11071181