Back to Search Start Over

Mini-Review: Tregs as a Tool for Therapy—Obvious and Non-Obvious Challenges and Solutions

Authors :
Elena I. Morgun
Irina A. Govorova
Maria B. Chernysheva
Maria A. Machinskaya
Ekaterina A. Vorotelyak
Source :
Cells, Vol 13, Iss 20, p 1680 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Tregs have the potential to be utilized as a novel therapeutic agent for the treatment of various chronic diseases, including diabetes, Alzheimer’s disease, asthma, and rheumatoid arthritis. One of the challenges associated with developing a therapeutic product based on Tregs is the non-selectivity of polyclonal cells. A potential solution to this issue is a generation of antigen-specific CAR-Tregs. Other challenges associated with developing a therapeutic product based on Tregs include the phenotypic instability of these cells in an inflammatory microenvironment, discrepancies between engineered Treg-like cells and natural Tregs, and the expression of dysfunctional isoforms of Treg marker genes. This review presents a summary of proposed strategies for addressing these challenges.

Details

Language :
English
ISSN :
20734409
Volume :
13
Issue :
20
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.6924c1ae56941bfbfa710e00300b9a2
Document Type :
article
Full Text :
https://doi.org/10.3390/cells13201680