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Mini-Review: Tregs as a Tool for Therapy—Obvious and Non-Obvious Challenges and Solutions
- Source :
- Cells, Vol 13, Iss 20, p 1680 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- Tregs have the potential to be utilized as a novel therapeutic agent for the treatment of various chronic diseases, including diabetes, Alzheimer’s disease, asthma, and rheumatoid arthritis. One of the challenges associated with developing a therapeutic product based on Tregs is the non-selectivity of polyclonal cells. A potential solution to this issue is a generation of antigen-specific CAR-Tregs. Other challenges associated with developing a therapeutic product based on Tregs include the phenotypic instability of these cells in an inflammatory microenvironment, discrepancies between engineered Treg-like cells and natural Tregs, and the expression of dysfunctional isoforms of Treg marker genes. This review presents a summary of proposed strategies for addressing these challenges.
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 13
- Issue :
- 20
- Database :
- Directory of Open Access Journals
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6924c1ae56941bfbfa710e00300b9a2
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cells13201680