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Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology

Authors :
Emanuele Murgo
Tommaso Colangelo
Maria Marina Bellet
Francesco Malatesta
Gianluigi Mazzoccoli
Source :
Biology, Vol 12, Iss 10, p 1354 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Neuronal PAS domain protein 2 (NPAS2) is a hemeprotein comprising a basic helix–loop–helix domain (bHLH) and two heme-binding sites, the PAS-A and PAS-B domains. This protein acts as a pyridine nucleotide-dependent and gas-responsive CO-dependent transcription factor and is encoded by a gene whose expression fluctuates with circadian rhythmicity. NPAS2 is a core cog of the molecular clockwork and plays a regulatory role on metabolic pathways, is important for the function of the central nervous system in mammals, and is involved in carcinogenesis as well as in normal biological functions and processes, such as cardiovascular function and wound healing. We reviewed the scientific literature addressing the various facets of NPAS2 and framing this gene/protein in several and very different research and clinical fields.

Details

Language :
English
ISSN :
12101354 and 20797737
Volume :
12
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.691ce749b1164947b5594c19f257d35c
Document Type :
article
Full Text :
https://doi.org/10.3390/biology12101354