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Induction and Modulation of EVs by Cigarette Smoke and Their Relevance in Lung Disease: Recent Advances
- Source :
- Journal of Respiration, Vol 3, Iss 4, Pp 164-177 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- Cigarette combustion has the potential to generate over 7000 chemicals, the majority of which are reactive free radicals that are known to trigger pro-inflammatory and carcinogenic responses. Numerous contemporary investigations have proposed that the pathophysiological and cellular mechanisms underlying the release of extracellular vesicles (EVs) in response to cigarette smoke (CS) may serve as potential pathways for CS-induced pathogenesis, while also reflecting the physiological state of the originating cells. This review provides a concise overview of the pathophysiological mechanisms linked to CS-induced EVs in various lung diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary fibrosis, and pulmonary hypertension. Additionally, it explores the potential and prospects of EVs as diagnostic biomarkers for CS-related lung diseases.
Details
- Language :
- English
- ISSN :
- 2673527X
- Volume :
- 3
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Respiration
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.68dd777866bb4e02962424f51d4602f2
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/jor3040016