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Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

Authors :
Michelle L. Krishnan
Juliette Van Steenwinckel
Anne-Laure Schang
Jun Yan
Johanna Arnadottir
Tifenn Le Charpentier
Zsolt Csaba
Pascal Dournaud
Sara Cipriani
Constance Auvynet
Luigi Titomanlio
Julien Pansiot
Gareth Ball
James P. Boardman
Andrew J. Walley
Alka Saxena
Ghazala Mirza
Bobbi Fleiss
A. David Edwards
Enrico Petretto
Pierre Gressens
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.68c92e894f6d4f89971dbd07d7ac5142
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00422-w