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Epithelial Mesenchymal Transition: a double‐edged sword

Authors :
Guislaine Barriere
Pietro Fici
Giulia Gallerani
Francesco Fabbri
Michel Rigaud
Source :
Clinical and Translational Medicine, Vol 4, Iss 1, Pp n/a-n/a (2015)
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

AbstractEpithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pathways have different regulations from those of normal physiology. In cancer invasion, such a mechanism leads to generation of circulating tumor cells. Epithelial cancer cells become motile mesenchymal cells able to shed from the primary tumor and enter in the blood circulation. This is the major part of the invasive way of cancer. EMT is also implicated in chronic diseases like fibrosis and particularly renal fibrosis. In adult organisms, healing is based on EMT which is beneficial to repair wounds even if it can sometimes exceed its goal and elicit fibrosis. In this review, we delineate the clinical significance of EMT in both physiological and pathological circumstances.

Details

Language :
English
ISSN :
20011326
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Clinical and Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.68bfcc623174226b503ef8b0064837a
Document Type :
article
Full Text :
https://doi.org/10.1186/s40169-015-0055-4