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Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-Based Cohort Study

Authors :
Matthew D. Seftel
Ivan Pasic
Gaganvir Parmar
Oliver Bucher
David S. Allan
Sita Bhella
Kevin Anthony Hay
Oluwaseun Ikuomola
Grace Musto
Anca Prica
Erin Richardson
Tony H. Truong
Kristjan Paulson
Source :
Current Oncology, Vol 30, Iss 11, Pp 9953-9967 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Background: Hematopoietic cell transplantation (HCT) is an established therapy for hematologic malignancies and serious non-malignant blood disorders. Despite its curative potential, HCT is associated with substantial toxicity and health resource utilization. Effective delivery of HCT requires complex hospital-based care, which limits the number of HCT centres in Canada. In Canada, the quantity, indications, temporal trends, and outcomes of patients receiving HCT are not known. Methods: A retrospective cohort study of first transplants reported to the Cell Therapy Transplant Canada (CTTC) registry between 2000 and 2019. We determined overall survival (OS) and non-relapse mortality (NRM), categorizing the cohort into early (2000–2009) and later (2010–2019) eras to investigate temporal changes. Results: Of 18,046 transplants, 7571 were allogeneic and 10,475 were autologous. Comparing the two eras, allogeneic transplants increased in number by 22.3%, with greater use of matched unrelated donors in the later era. Autologous transplants increased by 10.9%. Temporal improvements in NRM were observed in children and adults. OS improved in pediatric patients and in adults receiving autologous HCT. In adults receiving allogeneic HCT, OS was stable despite the substantially older age of patients in the later era. Interpretation: HCT is an increasingly frequent procedure in Canada which has expanded to serve older adults. Noted improvements in NRM and OS reflect progress in patient and donor selection, preparation for transplant, and post-transplant supportive care. In allogeneic HCT, unrelated donors have become the most frequent donor source, highlighting the importance of the continued growth of volunteer donor registries. These results serve as a baseline measure for quality improvement and health services planning in Canada.

Details

Language :
English
ISSN :
17187729 and 11980052
Volume :
30
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Current Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.68837b5ed0774b23892c3c247e8b55e7
Document Type :
article
Full Text :
https://doi.org/10.3390/curroncol30110723