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MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming
- Source :
- Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- MacroH2A histone variants are shown to mark a subset of enhancers in both normal and cancer cells. In mice, macroH2A deficiency is shown to facilitate increased activity of transcription stem cell-associated transcription factors.
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 6
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Communications Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.687c1bfb1c8f4aa091d8d2f3ab0a9055
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s42003-023-04571-1