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Steady-state distributions of nascent RNA for general initiation mechanisms
- Source :
- Physical Review Research, Vol 5, Iss 1, p 013064 (2023)
- Publication Year :
- 2023
- Publisher :
- American Physical Society, 2023.
-
Abstract
- Fluctuations in the number of nascent RNA accurately reflect transcriptional activity. However, mathematical models predicting their distributions are difficult to solve analytically due to their non-Markovian nature stemming from transcriptional elongation. Here we circumvent this problem by deriving an exact relationship between the steady-state distribution of nascent RNA and the distribution of initiation times, which can be computed for any general initiation mechanism described by a set of first-order reactions. We test our theory using simulations and live cell imaging data.
Details
- Language :
- English
- ISSN :
- 26431564
- Volume :
- 5
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Physical Review Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.687642ab69e44caba6c44d81e23b97ba
- Document Type :
- article
- Full Text :
- https://doi.org/10.1103/PhysRevResearch.5.013064