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Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men
- Source :
- Dermatology Reports, Vol 8, Iss 1 (2016)
- Publication Year :
- 2016
- Publisher :
- PAGEPress Publications, 2016.
-
Abstract
- The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0.384, r=0.025), however a positive correlation coefficient was identified in subjects above the age of 40. Based on the receiver operating characteristic curve analysis, 2D:4D does not predict the development of AGA. AGA is truly a multifactorial disease. Further, our findings suggest that increased in utero exposure to androgens as a fetus does not predispose men to develop AGA.
- Subjects :
- Androgenic alopecia
hair loss
digitlength ratio
predictive value
Dermatology
RL1-803
Subjects
Details
- Language :
- English
- ISSN :
- 20367392 and 20367406
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Dermatology Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.67f89c46000d458a85f72bb64b96fd51
- Document Type :
- article
- Full Text :
- https://doi.org/10.4081/dr.2016.6386