Back to Search Start Over

Marine-Derived Sulfated Glycans Inhibit the Interaction of Heparin with Adhesion Proteins of Mycoplasma pneumoniae

Authors :
Jiyuan Yang
Yuefan Song
Ke Xia
Vitor H. Pomin
Chunyu Wang
Mingqiang Qiao
Robert J. Linhardt
Jonathan S. Dordick
Fuming Zhang
Source :
Marine Drugs, Vol 22, Iss 5, p 232 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate, is critical in facilitating pathogen–host interactions, presenting a strategic target for therapeutic intervention. In this study, we assembled a glycan library comprising heparin, its oligosaccharide derivatives, and a variety of marine-derived sulfated glycans to screen the potential inhibitors for the pathogen–host interactions. By using Surface Plasmon Resonance spectroscopy, we evaluated the library’s efficacy in inhibiting the interaction between M. pneumoniae adhesion proteins and heparin. Our findings offer a promising avenue for developing novel therapeutic strategies against M. pneumoniae infections.

Details

Language :
English
ISSN :
16603397
Volume :
22
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.67ebfea3f0544ab5bdfa9a3a29c24e5e
Document Type :
article
Full Text :
https://doi.org/10.3390/md22050232