Back to Search Start Over

Speech-language within and between network disruptions in primary progressive aphasia variants

Authors :
Neha Singh-Reilly
Hugo Botha
Joseph R. Duffy
Heather M. Clark
Rene L. Utianski
Mary M. Machulda
Jonathan Graff-Radford
Christopher G. Schwarz
Ronald C. Petersen
Val J. Lowe
Clifford R. Jack, Jr
Keith A. Josephs
Jennifer L. Whitwell
Source :
NeuroImage: Clinical, Vol 43, Iss , Pp 103639- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Primary progressive aphasia (PPA) variants present with distinct disruptions in speech-language functions with little known about the interplay between affected and spared regions within the speech-language network and their interaction with other functional networks.The Neurodegenerative Research Group, Mayo Clinic, recruited 123 patients with PPA (55 logopenic (lvPPA), 44 non-fluent (nfvPPA) and 24 semantic (svPPA)) who were matched to 60 healthy controls. We investigated functional connectivity disruptions between regions within the left-speech-language network (Broca, Wernicke, anterior middle temporal gyrus (aMTG), supplementary motor area (SMA), planum temporale (PT) and parietal operculum (PO)), and disruptions to other networks (visual association, dorsal-attention, frontoparietal and default mode networks (DMN)).Within the speech-language network, multivariate linear regression models showed reduced aMTG-Broca connectivity in all variants, with lvPPA and nfvPPA findings remaining significant after Bonferroni correction. Additional loss in Wernicke-Broca connectivity in nfvPPA, Wernicke-PT connectivity in lvPPA and greater aMTG-PT connectivity in svPPA were also noted. Between-network connectivity findings in all variants showed reduced aMTG-DMN and increased aMTG-dorsal-attention connectivity, with additional disruptions between aMTG-visual association in both lvPPA and svPPA, aMTG-frontoparietal in lvPPA, and Wernicke-DMN breakdown in svPPA.These findings suggest that aMTG connectivity breakdown is a shared feature in all PPA variants, with lvPPA showing more extensive connectivity disruptions with other networks.

Details

Language :
English
ISSN :
22131582
Volume :
43
Issue :
103639-
Database :
Directory of Open Access Journals
Journal :
NeuroImage: Clinical
Publication Type :
Academic Journal
Accession number :
edsdoj.67ce0fdfcf9a4894abf06efac9019079
Document Type :
article
Full Text :
https://doi.org/10.1016/j.nicl.2024.103639