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BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Chronic pancreatitis is linked with an increased risk of pancreatic cancer. Here the authors show that genomic instability due to the loss of BRCA1 associated protein-1, frequently observed in patients with pancreatic cancer, is associated with chronic pancreatitis and predisposes to cancer development.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.67a5dd4c14849d2a389e9a68040dda2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-16589-8