Back to Search Start Over

Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes

Authors :
Qin Ma
Hengameh Shams
Alessandro Didonna
Sergio E. Baranzini
Bruce A. C. Cree
Stephen L. Hauser
Roland G. Henry
Jorge R. Oksenberg
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The combined analysis of single cell and bulk epigenetic datasets and multiple sclerosis GWAS reveals the enrichment of genetic susceptibility signals in B cells and monocyte-microglia cell types.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.675d0cabbd474edfbffe9c5abc5657bf
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04713-5