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Macrophage differentiation in enhancing hematopoietic function of ribonucleic acid for injection II via multi-omics analysis

Authors :
Yuan Li
Meng Teng
Siyu Li
Hongxin Yang
Yuebo Zhang
Meihua Cui
Lanzhou Li
Di Wang
Source :
Acta Materia Medica, Vol 3, Iss 3, Pp 289-304 (2024)
Publication Year :
2024
Publisher :
Compuscript Ltd, 2024.

Abstract

Ribonucleic acid for injection II is a clinical adjuvant cancer therapy treatment based on immunotherapy, which exerts its effects by enhancing immune function and suppressing tumor growth. However, the mechanism underlying the ameliorative effect on immunosuppressed hematopoietic dysfunction remains unclear. This study confirmed the immune-boosting and hematopoietic-promoting effects of ribonucleic acid for injection II, which has a wide distribution of molecular weights and is rich in amino acids and nucleotides. Ribonucleic acid for injection II influences the gut microbiota and serum metabolites to enhance immunity in immunosuppressed mice induced by CTX, while also mitigating bone marrow injury and increasing hematopoietic cells through mediating macrophage M1 differentiation, thereby improving hematopoietic dysfunction in mice.

Details

Language :
English
ISSN :
27377946
Volume :
3
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Materia Medica
Publication Type :
Academic Journal
Accession number :
edsdoj.670d49d48b96456ea7f64f97bd5edc3d
Document Type :
article
Full Text :
https://doi.org/10.15212/AMM-2024-0001