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Characterizing Hematological Changes Following Repeated Exposure to Non-Targeted Low-Dose Ionizing Radiation in Prostate Cancer Patients

Authors :
Allison E. Kennedy
Ian S. Dayes
Sameer Parpia
Douglas R. Boreham
Dawn M. E. Bowdish
Source :
Dose-Response, Vol 22 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

The duration and magnitude of haematological changes following non-targeted low-dose radiation have not been well explored. We previously reported that low-dose radiation (150 mGy 2x/week for 5 consecutive weeks) was well tolerated by participants (n = 15) with minimal toxicities and no changes in quality of life. Leukocytes, platelets and erythrocytes decreased from baseline measurement 12 months following treatment, however changes were not clinically significant. T-cells, NK-cells, B-cells and neutrophils were found to decrease during treatment and return to baseline levels by 3 months. The monocyte activation marker CD64 (FcγRI) was lower in participants whose cancer did not progress during the 12 month study follow up period, potentially giving insights into a biomarker of treatment success. Herein, we provide one of the most detailed descriptions of hematologic changes during low dose radiation treatment and during one year follow up. Low-dose radiation was associated with minor hematologic changes that mostly resolved by 3 months. (Clinical Trial Registered with the United States National Library of Medicine and National Institutes of Health under the title ‘Low Dose Hemi-Body Radiation for Recurrent Prostate Cancer’; ID: NCT03196778).

Subjects

Subjects :
Therapeutics. Pharmacology
RM1-950

Details

Language :
English
ISSN :
15593258
Volume :
22
Database :
Directory of Open Access Journals
Journal :
Dose-Response
Publication Type :
Academic Journal
Accession number :
edsdoj.6706d78d079d47b4aed1d24206c3fed5
Document Type :
article
Full Text :
https://doi.org/10.1177/15593258241276120