Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides

Metallated azomethine ylides are commonly used for the construction of N-heterocycles and α-amino acids. Here, the authors report a synergistic Cu/Ir-catalytic system that converts aldimine esters to a variety of chiral homoallylic amines via a cascade allylation/2-aza-Cope rearrangement.