Back to Search
Start Over
Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery
- Source :
- Microsystems & Nanoengineering, Vol 6, Iss 1, Pp 1-14 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Smartphone-powered drug delivery device A device developed by researchers in China uses a microneedle array to efficiently and painlessly deliver precise doses of insulin and can be used by patients without help from medical staff. The new system was developed by a team led by Xi Xie and Lelun Jiang of Sun Yat-Sen University. The array of microneedles is pressed against the skin to create micro-holes and then automatically retracted. A mild electric current then drives charged nanovesicles carrying insulin through the holes. The circuit is powered and controlled via a smartphone, which can alter the intensity of the current to determine the dosage of insulin delivered. The team showed that the device effectively delivered insulin to a diabetic rat model with no obvious harmful effects. It thus offers a powerful tool for efficient, controllable, and convenient delivery of macromolecular drugs.
- Subjects :
- Technology
Engineering (General). Civil engineering (General)
TA1-2040
Subjects
Details
- Language :
- English
- ISSN :
- 20557434
- Volume :
- 6
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Microsystems & Nanoengineering
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.66d60c631d8749f5bdf5a12292f77d5a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41378-020-00224-z