Back to Search Start Over

Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery

Authors :
Jingbo Yang
Yanjun Li
Rui Ye
Ying Zheng
Xiangling Li
Yuzhen Chen
Xi Xie
Lelun Jiang
Source :
Microsystems & Nanoengineering, Vol 6, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Publishing Group, 2020.

Abstract

Smartphone-powered drug delivery device A device developed by researchers in China uses a microneedle array to efficiently and painlessly deliver precise doses of insulin and can be used by patients without help from medical staff. The new system was developed by a team led by Xi Xie and Lelun Jiang of Sun Yat-Sen University. The array of microneedles is pressed against the skin to create micro-holes and then automatically retracted. A mild electric current then drives charged nanovesicles carrying insulin through the holes. The circuit is powered and controlled via a smartphone, which can alter the intensity of the current to determine the dosage of insulin delivered. The team showed that the device effectively delivered insulin to a diabetic rat model with no obvious harmful effects. It thus offers a powerful tool for efficient, controllable, and convenient delivery of macromolecular drugs.

Details

Language :
English
ISSN :
20557434
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Microsystems & Nanoengineering
Publication Type :
Academic Journal
Accession number :
edsdoj.66d60c631d8749f5bdf5a12292f77d5a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41378-020-00224-z