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Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane
- Source :
- Polymers, Vol 7, Iss 2, Pp 281-297 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane.
- Subjects :
- basement membrane
laminin
peptides
polysaccharide
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 20734360
- Volume :
- 7
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Polymers
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.66be1ba72cd432fb6a37b994ad1cb65
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/polym7020281