Factors Influencing Glucose Response to Exercise Following Oral Glucose Load

PURPOSE Exercise can reduce postprandial hyperglycemia by increasing contraction-mediated glucose uptake in skeletal muscles. However, postprandial exercise does not always have similar effects in all patients. This study aimed to analyze the factors influencing glucose response to exercise following oral glucose load. METHODS We enrolled 169 adults with impaired glucose tolerance (IGT, n=64) and type 2 diabetes (T2D, n=105). We measured fingertip capillary blood glucose level at 30-minute intervals over 2-hour after the 75-g oral glucose ingestion. In addition, a single bout of moderate-intensity aerobic exercise was conducted at 30 minutes after 75-g oral glucose ingestion. We also measured glycated hemoglobin (HbA1c), insulin, insulin resistance (HOMA-IR), β-cell function (HOMA-β), physical activity level questionnaire and anthropometrics. RESULTS There was a significant difference in glucose concentration between the IGT and T2D groups (p