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The role of HGF/c-MET signaling pathway in lymphoma
- Source :
- Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-8 (2016)
- Publication Year :
- 2016
- Publisher :
- BMC, 2016.
-
Abstract
- Abstract Inappropriate activation of c-mesenchymal-epithelial transition (MET), the receptor tyrosine kinase (RTK) for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and represented a promising therapeutic target for developing anticancer agents. In contrast to other solid tumors, there are limited data describing the functional role of HGF/c-MET signaling pathway in lymphoma. In the current review, we summarize recent findings about the expression, cellular mechanisms/functions, and therapeutic application of HGF/c-MET in different types of lymphoma, especially B cell lymphoma, T and NK cell lymphoma, and Hodgkin lymphoma. We also discuss the existing problems and future directions about studying the HGF/c-MET pathway in lymphoma cells.
Details
- Language :
- English
- ISSN :
- 17568722
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Hematology & Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.669dfb84a4f2fad6570129edfaf19
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13045-016-0366-y