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Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3

Authors :
Yu Aoh
Han-Jun Hsiao
Ming-Kuei Lu
Antonella Macerollo
Hui-Chun Huang
Masashi Hamada
Chon-Haw Tsai
Jui-Cheng Chen
Source :
Frontiers in Neurology, Vol 10 (2019)
Publication Year :
2019
Publisher :
Frontiers Media S.A., 2019.

Abstract

Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3.Methods: We assessed ERD/ERS of self-paced voluntary hand movements in 15 patients with genetically proven SCA3 in comparison with healthy controls.Results: In ERS, a significant interaction effect between group, frequency, and period (F = 1.591; p = 0.005; ρI = 0.86) was observed. The post-hoc two-tailed independent t-test showed significant differences in high beta and low beta ERS. By contrast, in ERD, no apparent differences were observed in the pattern of patients with SCA3 in comparison with healthy controls (F = 1.01; p = 0.442).Conclusion: The study revealed a decreased ERS in patients with SCA3, especially at the frequency of 20–30 Hz. This study elucidates the significant role of cerebellum in motor control.

Details

Language :
English
ISSN :
16642295
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neurology
Publication Type :
Academic Journal
Accession number :
edsdoj.668122bce5b481483644293c5bde63e
Document Type :
article
Full Text :
https://doi.org/10.3389/fneur.2019.00822