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Targeting hypoxic tumour cells to overcome metastasis

Authors :
Bennewith Kevin L
Dedhar Shoukat
Source :
BMC Cancer, Vol 11, Iss 1, p 504 (2011)
Publication Year :
2011
Publisher :
BMC, 2011.

Abstract

Abstract The microenvironment within solid tumours can influence the metastatic dissemination of tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary tumours can also affect the survival and proliferation of metastatic tumour cells in distant organs. Hypoxic tumour cells have been historically targeted during radiation therapy in attempts to improve loco-regional control rates of primary tumours since hypoxic cells are known to be resistant to ionizing radiation-induced DNA damage. There are, therefore, a number of therapeutic strategies to directly target hypoxic cells in primary (and metastatic) tumours, and several compounds are becoming available to functionally inhibit hypoxia-induced proteins that are known to promote metastasis. This mini-review summarizes several established and emerging experimental strategies to target hypoxic cells in primary tumours with potential clinical application to the treatment of patients with tumour metastases or patients at high risk of developing metastatic disease. Targeting hypoxic tumour cells to reduce metastatic disease represents an important advance in the way scientists and clinicians view the influence of tumour hypoxia on therapeutic outcome.

Details

Language :
English
ISSN :
14712407
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.663aa528e4a248669a6b0a9b2ec5a74b
Document Type :
article
Full Text :
https://doi.org/10.1186/1471-2407-11-504