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Molecular Networks Involved in the Immune Control of BK Polyomavirus
- Source :
- Clinical and Developmental Immunology, Vol 2012 (2012)
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- BK polyomavirus infection is the important cause of virus-related nephropathy following kidney transplantation. BK virus reactivates in 30%–80% of kidney transplant recipients resulting in BK virus-related nephropathy in 1%–10% of cases. Currently, the molecular processes associated with asymptomatic infections in transplant patients infected with BK virus remain unclear. In this study we evaluate intrarenal molecular processes during different stages of BKV infection. The gene expression profiles of 90 target genes known to be associated with immune response were evaluated in kidney graft biopsy material using TaqMan low density array. Three patient groups were examined: control patients with no evidence of BK virus reactivation (n=11), infected asymptomatic patients (n=9), and patients with BK virus nephropathy (n=10). Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P
- Subjects :
- Immunologic diseases. Allergy
RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 17402522 and 17402530
- Volume :
- 2012
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.65ef676ffeb042ab9c5317b24a5439a8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2012/972102