Preventive treatment of migraine

Many of the patients with migraine require a preventive therapy to reduce frequency, severity and duration of the crisis, to improve the quality of life, and to improve the responsse to abortive theraphy of attacks. The treatment can be pharmacological, non pharmacological, or the combination of both. This article reviews the indications for the prophylaxis of migraine, the different drugs that are, their mechanisms of actions, their adverse effects therapeutic limitations, and cautions when combining the abortive and prophylactic therapy of migraine.