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TRIM24 is an insulin-responsive regulator of P-bodies
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Insulin promotes hepatic lipogenesis, though underlying regulation remains unclear. Here the authors show that insulin translocates TRIM24 from the nucleus into cytosolic P-bodies to stabilise hepatic PparĪ³ mRNA, and that inactivation of TRIM24 promotes PparĪ³ degradation and alleviates hepatosteatosis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.650982c3422c4c15b2d3e44d430ecab4
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-31735-0