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Clinical features of cardiac lesion in patients with generalized sarcoidosis

Clinical features of cardiac lesion in patients with generalized sarcoidosis

Authors :
E N Popova
L A Strizhakov
V I Sholomova
A B Ponomarev
S V Moiseev
M U Brovko
I B Bondarenko
L A Ponomareva
V V Fomin
Source :
Терапевтический архив, Vol 90, Iss 1, Pp 54-59 (2018)
Publication Year :
2018
Publisher :
"Consilium Medicum" Publishing house, 2018.

Abstract

The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immunosuppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice.

Details

Language :
Russian
ISSN :
00403660 and 23095342
Volume :
90
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Терапевтический архив
Publication Type :
Academic Journal
Accession number :
edsdoj.6501c2acdb249d780f16af4d442c40f
Document Type :
article
Full Text :
https://doi.org/10.17116/terarkh201890154-59