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Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST

Authors :
Yahui Long
Kok Siong Ang
Mengwei Li
Kian Long Kelvin Chong
Raman Sethi
Chengwei Zhong
Hang Xu
Zhiwei Ong
Karishma Sachaphibulkij
Ao Chen
Li Zeng
Huazhu Fu
Min Wu
Lina Hsiu Kim Lim
Longqi Liu
Jinmiao Chen
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Advances in spatial transcriptomics technologies have enabled the gene expression profiling of tissues while retaining spatial context. Here the authors present GraphST, a graph self-supervised contrastive learning method that learns informative and discriminative spot representations from spatial transcriptomics data.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.64eff60cbac44eeaa66e55116960786f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36796-3