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Plasma Cell-Free DNA as a Novel Biomarker for the Diagnosis and Monitoring of Atherosclerosis

Authors :
Benheng Qian
Kexin Li
Xiaoying Lou
Ye Guo
Yidong Wang
Lianpin Wu
Donghong Zhang
Source :
Cells, Vol 11, Iss 20, p 3248 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Atherosclerosis (AS) is the leading cause of cardiovascular diseases (CVDs) with a high rate of mortality worldwide. Plasma cell-free DNA (cfDNA), mainly originating from apoptosis, necrosis, and active secretion, has been recognized as a promising biomarker for the diagnosis and prognosis of multiple cancers, whereas there are no reports about cfDNA in CVDs. Here, we found an increased quantity and decreased integrity of cfDNA (cfDI) in the serum from AS patients compared with normal controls. Moreover, the reduced cfDI is inversely correlated with serum LDL levels, carotid plaque size, and carotid plaque thickness in the progression of AS. Consistently, in vivo experiments confirmed that the release and cleavage of cfDNA were increased concomitantly with the development and progression of AS in ApoE−/− mice. Our study sheds light on the potential of cfDNA and cfDI as molecular biomarkers for detecting and monitoring AS.

Details

Language :
English
ISSN :
20734409
Volume :
11
Issue :
20
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.64d7715d0e6f47daa67c34049f4266bc
Document Type :
article
Full Text :
https://doi.org/10.3390/cells11203248