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Gene activation guided by nascent RNA-bound transcription factors

Authors :
Ying Liang
Haiyue Xu
Tao Cheng
Yujuan Fu
Hanwei Huang
Wenchang Qian
Junyan Wang
Yuenan Zhou
Pengxu Qian
Yafei Yin
Pengfei Xu
Wei Zou
Baohui Chen
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Gene activation methods are valuable for studying gene functions and may have potential applications in bioengineering and medicine. Here the authors developed Narta technology to achieve gene activation by recruiting artificial transcription factors to transcription sites through nascent RNAs of the target gene.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.646bd1aba514b948676d33910aaf524
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-35041-7