Back to Search
Start Over
Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases
- Source :
- International Journal of Rheumatology, Vol 2012 (2012)
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- The performance of the interferon gamma release assays (IGRAs) and tuberculin skin test (TST) was reviewed retrospectively in patients with psoriasis, inflammatory musculoskeletal diseases, or miscellaneous inflammatory conditions. The study was carried out over a 22-month period using 109 records of patients with psoriasis (𝑛=21), musculoskeletal disease (𝑛=74), or other inflammatory conditions (𝑛=14). Forty-four (48%) of 109 patients were on immunosuppressive therapy and 38/109 (35%) on systemic glucocorticoid therapy. The agreement between the IGRAs was substantial (𝜅=0.71) whilst that between the IGRAs and TST was low (𝜅=0.32). Logistic regression models revealed that IGRAs associated with risk factors for latent tuberculosis infection better than TST. TST was influenced by age, BCG vaccination, sex, and glucocorticoid therapy. We found that IGRAs performed equally well with low level of indeterminate results (1-2%). IGRAs were superior to TST because the latter was influenced by BCG-vaccination status and immunosuppressive therapy.
- Subjects :
- Diseases of the musculoskeletal system
RC925-935
Subjects
Details
- Language :
- English
- ISSN :
- 16879260 and 16879279
- Volume :
- 2012
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.64453b0bc02d4b8c8f141caca3e8a93d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2012/381929