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Retinal necrosis and apoptosis changes in mice under simulated microgravity

Retinal necrosis and apoptosis changes in mice under simulated microgravity

Authors :
Zhen-Fei Yang
Wen-Jiong Li
Peng Zhang
Xu Zha
Xiao Li
Xiao-Ping Chen
Si-Quan Zhu
Source :
Guoji Yanke Zazhi, Vol 22, Iss 11, Pp 1765-1770 (2022)
Publication Year :
2022
Publisher :
Press of International Journal of Ophthalmology (IJO PRESS), 2022.

Abstract

AIM: To investigate whether the microgravity environment is related to retinal damage.METHODS: Hanging-tail mice tests were used to simulate weightlessness. Light microscopy, and transmission electron microscopic examinations of the retinal tissue structure were used to observe morphological changes. Immunohistochemistry and Western blot analyses were performed to detect the molecular changes associated with the observations.RESULT: Light microscopy and transmission electron microscopy demonstrated that more dead cells were detected in the ganglion layer and inner nuclear layer cells. TNF-α and caspase-3 protein expression in the retinas of simulated microgravity groups were up-regulated compared with the ground-based control group.CONCLUSION: The results demonstrated that simulated microgravity produced severe pathological damage in the retinas of mice.

Details

Language :
English
ISSN :
16725123
Volume :
22
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Guoji Yanke Zazhi
Publication Type :
Academic Journal
Accession number :
edsdoj.643b63041c744a25bbc2656861b1077b
Document Type :
article
Full Text :
https://doi.org/10.3980/j.issn.1672-5123.2022.11.01