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Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck

Authors :
Razvan Iacob
Matei Mandea
Speranta Iacob
Catalina Pietrosanu
Doru Paul
Razvan Hainarosie
Cristian Gheorghe
Source :
Frontiers in Medicine, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications.

Details

Language :
English
ISSN :
2296858X
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.6435d6e3ff45328da4b6df69d7bddc
Document Type :
article
Full Text :
https://doi.org/10.3389/fmed.2022.827297