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Research Progress of Natural Active Substances with Immunosuppressive Activity

Authors :
Fei Shao
Qiying Shen
Zhengfei Yang
Wenqian Yang
Zixiang Lu
Jie Zheng
Liming Zhang
Hangying Li
Source :
Molecules, Vol 29, Iss 10, p 2359 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The increasing prevalence of autoimmune diseases globally has prompted extensive research and the development of immunosuppressants. Currently, immunosuppressive drugs such as cyclosporine, rapamycin, and tacrolimus have been utilized in clinical practice. However, long-term use of these drugs may lead to a series of adverse effects. Therefore, there is an urgent need to explore novel drug candidates for treating autoimmune diseases. This review aims to find potential candidate molecules for natural immunosuppressive compounds derived from plants, animals, and fungi over the past decade. These compounds include terpenoids, alkaloids, phenolic compounds, flavonoids, and others. Among them, compounds 49, 151, 173, 200, 204, and 247 have excellent activity; their IC50 were less than 1 μM. A total of 109 compounds have good immunosuppressive activity, with IC50 ranging from 1 to 10 μM. These active compounds have high medicinal potential. The names, sources, structures, immunosuppressive activity, and the structure-activity relationship were summarized and analyzed.

Details

Language :
English
ISSN :
29102359 and 14203049
Volume :
29
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.642b6bca95304831b56edf4d32350277
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules29102359