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Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

Authors :
Stefanie R. Bailey
Michelle H. Nelson
Kinga Majchrzak
Jacob S. Bowers
Megan M. Wyatt
Aubrey S. Smith
Lillian R. Neal
Keisuke Shirai
Carmine Carpenito
Carl H. June
Michael J. Zilliox
Chrystal M. Paulos
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.63f1a5f94c67463f9202a2a71250b8b7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01867-9